解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Mitochondrial dysfunction has been proposed to be one of the earliest triggering events in isoflurane-induced neuronal damage. Lidocaine has been demonstrated to attenuate the impairment of cognition in aged rats induced by isoflurane in our previous study. In this study, we hypothesized that lidocaine could attenuate...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02799-0
更新日期:2019-07-01 00:00:00
abstract::Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2701-x
更新日期:2019-06-01 00:00:00
abstract::Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN). Mechanistic evidence of this role has previously only been provided through transcriptional or translational depletion of total APP levels. However, numer...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02747-y
更新日期:2019-06-01 00:00:00
abstract::Menadione (2-methyl-1,4-naphthoquinone) is a synthetic derivative of vitamin K that allows rapid redox cycling in cells and thereby generates reactive oxygen species (ROS). To test for the consequences of a treatment of brain astrocytes with menadione, we incubated primary astrocyte cultures with this compound. Incuba...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02760-1
更新日期:2019-05-01 00:00:00
abstract::Role of the orexinergic system in pain modulation is well studied and involvement of the spinal orexin-1 receptors is well documented. In this study, we examined role of the spinal orexin-2 receptors in modulation of inflammatory pain in rat. Fifty-one adult male Wistar rats were implanted unilaterally with a guide ca...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02749-w
更新日期:2019-05-01 00:00:00
abstract::Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxa...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02733-4
更新日期:2019-04-01 00:00:00
abstract::Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02728-1
更新日期:2019-04-01 00:00:00
abstract::Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02734-3
更新日期:2019-04-01 00:00:00
abstract::Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2676-7
更新日期:2019-02-01 00:00:00
abstract::VGF nerve growth factor inducible (VGF) is a neuropeptide precursor induced by brain-derived neurotrophic factor and nerve growth factor. VGF is increased in the prefrontal cortex and cerebrospinal fluid in schizophrenia patients. In our previous study, VGF-overexpressing mice exhibited schizophrenia-like behaviors an...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2684-7
更新日期:2019-02-01 00:00:00
abstract:: ...
journal_title:Neurochemical research
pub_type: 传,社论,历史文章
doi:10.1007/s11064-018-02702-3
更新日期:2019-01-01 00:00:00
abstract::Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-017-2459-6
更新日期:2019-01-01 00:00:00
abstract::Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and intracellular trafficking proper function has been suggested to be caused by α-synuclein toxicity, which is also associated with the higher le...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-018-2673-x
更新日期:2018-12-01 00:00:00
abstract::Developing cellular models of sporadic Alzheimer's disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells (iPSCs) has revolutionised the opportunities to model AD pathology, in...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-018-2663-z
更新日期:2018-12-01 00:00:00
abstract::Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of gli...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2626-4
更新日期:2018-11-01 00:00:00
abstract::Neuropeptides are derived from large and inactive proteins which require endoproteolytic processing for the biosynthesis of the bioactive peptides. The maturation of pro-neuropeptide to neuropeptide is believed to be performed by ortholog pro-protein convertase EGL-3 in Caenorhabditis elegans (C. elegans). Furthermore...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2636-2
更新日期:2018-11-01 00:00:00
abstract::Epileptogenesis, induced by status epilepticus (SE), is a chronic process, and intervention in this progress may prevent chronic epilepsy. It has been proposed that DNA methylation might be related with epileptogenesis. RASgrf1 has a differentially methylated region at the promoter which can silence gene expression. W...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2621-9
更新日期:2018-10-01 00:00:00
abstract::MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is invol...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-018-2602-z
更新日期:2018-10-01 00:00:00
abstract::Alcohol abuse affects several neurological pathways and causes significant alterations in the brain. Abstention from alcohol causes only a marginal decrease in oxidative stress and neuro inflammation. Our previous studies had shown that an active metabolite of vitamin A, all trans retinoic acid (ATRA), ameliorates alc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2595-7
更新日期:2018-09-01 00:00:00
abstract::Systemic inflammation is present in obesity and emerging evidence, primarily from studies using male rodents fed high-fat diets, suggests neuroimmune signaling also is involved. We investigated early changes in neuroimmune signaling during the weight gain that follows ovariectomy in rats. Ovariectomized (OVX) rats wer...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2596-6
更新日期:2018-09-01 00:00:00
abstract::To assess the therapeutic effects of microRNA-21 (miR-21) knockdown (KD) for acute thoracic spinal cord contusion using a mouse model. Forty C57/BL6 mice were randomly divided into four groups: mice in the sham-operated (Sham) group received surgical procedure without spinal cord contusion; the spinal cord injury (SCI...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2580-1
更新日期:2018-08-01 00:00:00
abstract::The aim of this study was to determine the anticancer potential of Leonurus sibiricus extract derived from in vitro transgenic roots transformed by Agrobacetrium rhizogenes with AtPAP1 transcriptional factor, and that of transformed roots without construct, on grade IV human glioma cells and the U87MG cell line, and a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2551-6
更新日期:2018-07-01 00:00:00
abstract::Radioactive 125I seeds-based radiotherapy has achieved great success in treatment of human cancers. However, radioresistance and severe side effects badly limited its clinic application. Recently, chemoradiotherapy as a superior strategy has been rapidly developed and widely used in clinic. However, the underlying mec...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2547-2
更新日期:2018-07-01 00:00:00
abstract::The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subsequent inflammation-rel...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2544-5
更新日期:2018-06-01 00:00:00
abstract::Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervo...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2505-z
更新日期:2018-05-01 00:00:00
abstract::Kv1.3 is a voltage gated potassium channel that has been implicated in pathophysiology of multiple sclerosis (MS). In the present study we investigated temporal and cellular expression pattern of this channel in the lumbar part of spinal cords of animals with experimental autoimmune encephalomyelitis (EAE), animal mod...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2509-8
更新日期:2018-05-01 00:00:00
abstract::It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2486-y
更新日期:2018-04-01 00:00:00
abstract::Spinal cord injury (SCI) is a type of long-term disability with a high morbidity rate in clinical settings for which there is no effective clinical treatment to date. Usually, lithium is used as a popular mood stabilizer. Recently, growing evidence has shown that lithium has clear neuroprotective effects after SCI, an...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2488-9
更新日期:2018-04-01 00:00:00
abstract::Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2477-z
更新日期:2018-03-01 00:00:00
abstract::Altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of Alzheimer's disease, which highlights the occurrence of endoplasmic reticulum stress and triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adapt...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2469-z
更新日期:2018-03-01 00:00:00
abstract::6-Hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS) that are associated with various neurodegenerative diseases such as Parkinson's disease. 3,3',4',7-Tetrahydroxyflavone (fisetin), a plant flavonoid has a variety of physiological effects such as antioxidant activity. In this study, we i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2445-z
更新日期:2018-02-01 00:00:00
abstract::Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2430-6
更新日期:2018-02-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The spelling of the author Tommaso Ianniti was incorrect and has been corrected as Tommaso Iannitti. The original article has been corrected. ...
journal_title:Neurochemical research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11064-018-2468-0
更新日期:2018-02-01 00:00:00
abstract::Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2426-2
更新日期:2018-02-01 00:00:00
abstract::Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-017-2318-5
更新日期:2018-01-01 00:00:00
abstract::Activation of glial cells has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Aggregation of amyloid β (Aβ) is profusely observed as characteristic pathology in AD brain. In our previous study using microglial cell line BV-2, tissue-type transglutaminase (TG2) was found to be involved i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2284-y
更新日期:2018-01-01 00:00:00
abstract::The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons....
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-017-2441-3
更新日期:2018-01-01 00:00:00
abstract::Due to the biological importance of sodium and its relative scarcity within many natural environments, 'salt appetite' has evolved whereby dietary salt is highly sought after and palatable when tasted. In addition to peripheral responses, salt depletion is detected within the brain via circumventricular organs and 11β...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-017-2336-3
更新日期:2018-01-01 00:00:00
abstract::Silibinin has been widely used to treat liver diseases due to its antioxidant activity. However, the effects of silibinin on the central nervous system have not been thoroughly investigated. The pathological hallmarks of Alzheimer's disease are the accumulation of amyloid β protein, development of neurofibrillary tang...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2389-3
更新日期:2017-12-01 00:00:00
abstract::Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-017-2382-x
更新日期:2017-12-01 00:00:00